The bad news is that energy efficiency has understandably never been job one in the pharmaceutical industry. The good news is that opportunities abound for real progress as a new emphasis on sustainability grows. The author offers more than a daily dose of industry-specific insight while outlining why higher efficiency need not be a bitter pill to swallow.

Historically, pharmaceutical facilities have been designed with little regard to energy efficiency. Product quality has, rightly, trumped all other considerations. Systems have been designed for greatest assurance of consistent environmental conditions, with constant volume / reheat and high air change rates the order of the day. Steps to prevent cross-contamination in multi-product plants have been draconian, ranging from 100% fresh air/exhaust to multiple series HEPA filters in supply and exhaust.

Figure 1. Recent regulatory developments and the rise of the risk-based approach.

Concerns for sustainability and energy efficiency challenge these practices and cause us to ask the question, “Can we protect the patient without sacrificing the planet?” Developments in processing equipment, isolation technology and a risk/science-based approach to ensuring parameters of “strength, identity, safety, purity, and quality,” open a new world of possibilities for HVAC in biotech and pharmaceutical facilities.

In this article, we will explore principles to apply in the first step of the HVAC design process to yield greater energy efficiency.


Global regulators are leading the way by challenging the life sciences industry to take a different approach to setting parameters for product processing. Gone are the days of “risk avoidance,” when designers were encouraged to eliminate every conceivable risk - regulation now focuses on “risk management and product knowledge.”

Applying this systems thinking to pharmaceutical manufacturing lowers the cost of drug manufacturing while improving quality by focusing energy on product knowledge and minimizing non-value added activities. This is great for sustainability. In the past, challenging HVAC practices in biotech and pharmaceutical facilities at the most fundamental level ran headlong into the desire to eliminate risk. Corporate standards for environmental conditions, air change rates, percentage of fresh air, etc., handcuffed the HVAC engineer by making conservative rules of thumb mandatory.

Figure 2. Sterile manufacturing particle counts, in operation.

Now more than ever, regulators and quality professionals are open to the idea of managing the risks inherent in environmental control rather than attempting to eliminate them (and creating new ones in the process). This requires a cross-functional approach, engaging the departments of quality, development, and manufacturing with engineering in collaboration to establish a design that’s both efficient and effective.

Statement of Principles for Sustainable Pharmaceutical HVAC
  • Don’t apply standards blindly.
  • Utilize enough air to reliably produce the desired results, don’t focus solely on air change rates.
  • Turn down airflows when not in use.
  • Consider all air filtration in caluclations to produce desired conditions.
  • Recirculate air whenever safe and practical.
  • Broaden temperature and rh limits as much as allowable by the product and process.
  • Use micro-environments wherever practical.

The following recommendations all come with the same caveat; as we’ve outlined above, it’s incumbent on the user and designer to verify the actual needs and risks of their process and prove the effectiveness of the implemented system.

Air Change Rates

Historically, rules of thumb for pharmaceutical cleanrooms have specified air change rates starting at 20 ach for ISO 8 and 9 (Grade C and D) rooms and increasing to 40, 60, and sometimes even 100 for ISO 7 (Grade B) spaces. Real-world environmental monitoring, however, shows that rooms operating at these air-change rates often achieve dynamic contamination levels orders of magnitude cleaner than specified.

In Figure 2, the cleanrooms achieve particle counts 1.5 to 2 orders of magnitude better than specified. Why is this? One reason is that while air change rates relate inversely to the recovery of a room and the time it takes to reach steady state, it’s the particle generation rates and the diluting (or displacing) airflow that really influence the particle count achieved. If we neglect the contribution from supply air (which should be small) the steady state concentration can be approximated as: Cf= Ci+( (PGRpx N) +PGRm)/Q )


Cf= Room particle count (particles/volume)

Ci= Initial particle count (particles/volume)

PGRp= Particle generation rate from people (particles/person minute)

PGRm= Particle generation rate from process (particles/minute)

N = Number of people in the clean room

Q = supply air volume/minute

Another reason is that personnel are a key source of particulates, advances in gowning, automation, and isolation have decreased how many people are in the cleanroom and how much they shed, which has had a huge impact on modern cleanroom performance.

If we design cleanrooms by evaluating the particle generation rates and providing enough diluting (or displacing) airflow, rather than using rules of thumb for air changes, we can create more efficient cleanrooms and may save 10% to 30% of cleanroom energy consumption.

Airflow and Environmental Setbacks

Office and laboratories often benefit from an off-hours or unoccupied setback of environmental conditions. These schemes usually include a reduction in airflow (sometimes a shutdown of AHUs altogether) and a relaxation of temperature and rh setpoints for energy savings. Can these energy-saving schemes be applied to pharmaceutical manufacturing?

When tested “at rest” (without people), cleanrooms typically perform one to two orders of magnitude better than “in operation.” In fact, Annex 1, the European guidance for “Manufacture of Sterile Medicinal Products” specifies this level of performance at rest.

Figure 3. Typical cleanroom recovery performance.

In addition, Annex 1 requires that sterile manufacturing areas be tested “in operation,” “at rest,” and that the “recovery” time be recorded (the time required for the transition) (Figure 3).

We can leverage the exceeding performance when at rest to establish a protocol for reduced airflow and relaxed environmental controls during idle periods. What’s more, recovery testing suggests a method of test (MOT is found in ISO 14644-3) for proving the restoration of manufacturing conditions.

We suggest the following parameters be considered in establishing an idle “setback” for environmental conditions in pharmaceutical manufacturing facilities:
  • Do not store product or product contact materials open within the space during setback periods;
  • Maintain sufficient ventilation to offset heat gains;
  • Maintain design pressure differentials to adjacent spaces for contamination control;
  • Consider mold and microbial growth conditions when arriving at relaxed rh setpoints (exceeding 80% rh is not recommended );
  • Consider thermal inertia in equipment and construction when arriving at relaxed temperature setpoints;
  • Verify the time required to restore environmental conditions after an idle period via EM testing.
It is clear that many pharmaceutical cleanrooms can maintain conditions when at rest with a fraction of the airflow needed during operation. Establishing a setback scenario for idle periods may allow for significant savings without impacting product quality.


The prevention of cross-contamination of facilities engaged in concurrent manufacturing of multiple products has driven the prevalence of double HEPA filtration in this application and in some single product plants (this includes multi-product campaign facilities). Double HEPA filters are a very positive method of controlling the HVAC system as a path of cross-contamination. But is there a lower energy alternative?

Figure 4. A composite efficiency profile of MERV-rated filters related by particle size, based on initial conditions. (Graph courtesy of NAFA, Summer 2002 issue of Air Media. Author(s): W. J. Kowalski, P.E., Ph.D. and W. P. Bahnfleth, P.E., Ph.D., The Pennsylvania State University.)

When considering cross-contamination, it is the mass of “Drug A” that could contaminate “Drug B” that is of critical importance, not the particle count. This mass-based approach is similar to that used in personnel safety calculations, where environmental contamination produced by the process (usually expressed in mcg/m3) is mitigated by a series of controls and compared to an acceptable operator exposure. Similarly, cleaning validations typically performed set an acceptable residual mass of a product which might be carried into another product. Leveraging these techniques, we can evaluate the ability of our HVAC system to stop airborne mass cross-contamination.

Table 1. Particulate generation by gowning and activity stated in particles/min.

HVAC systems are usually equipped with an array of filters designed primarily to clean outdoor air. In typical outdoor air it’s estimated that are more than 90% of particles and are less than 1.0 micron in size, low-efficiency filters do a good job at removing large particles, but miss the larger number of these small particles (Figure 4). However, since the mass of a particle increases as roughly the cube of its size, particles less than 1 micron represent less than 30% of the total mass and particles under 0.5 microns represent less than 1%! Due to this cubic relationship our low-efficiency filters can be very effective at removing mass (Table 2).

Table 2. These comparisons of filter rating systems are only approximate as the test methods are different.

The final factor to include in our calculations is the additive nature of filter efficiency. Each filter presents a lower concentration of particulate to the succeeding filter in an array, making the total cascade the product of the efficiency of the component filters. With these factors in mind and using the ASHRAE 52.1 arrestance as the gravimetric mass efficiency, we can approximate the cross-contamination protection provided by a typical filter arrangement of MERV 7, 11, and 16 as providing greater than a four-log reduction in mass. What’s more, a high-capacity MERV 13 and HEPA yields a six-log reduction with lower pressure drop.

While the ever-increasing potency of compounds imposes an escalating burden of care in the prevention of cross-contamination, accounting for the protection afforded by all filters in a system allows for lower pressure drops than dual HEPAs and further energy savings.


Conditioned fresh air can consume two to five times the energy of recirculated air. The effectiveness of filtration in removing the mass of contaminants reveals another opportunity for energy savings. By employing appropriate filtration, we can trade fan horsepower for the much larger chiller, cooling tower, pump, and boiler horsepower. The application of systems like those outlined above or double HEPA filtration produces an 8-log reduction in mass. With this high reduction in mass, a failure of any single element, the system will retain a 2- to 4-log protection, which may be sufficient for lower potency products.

Figure 5. Central station outside air AHU with local recirculation.

Of course, when using highly potent compounds, the risk of cross-contamination is increased. This risk can be abated by an air handling configuration that employs a central station air handler for fresh air with multiple recirculation units, dedicated to a particular room or suite for by-products (Figure 5).

Using this scheme, we can achieve the product separation that potent multi-product plants require, with 50% to 80% less energy usage than systems using 100% outside air (OA).

Broad Temperature and RH limits

In the setting of temperature and rh setpoints, we have also seen the prevalence of application of rules of thumb which may not be linked with the product or process requirements. The conservatism is well appreciated, and failure to recognize a product/process rh requirement could result in significant product quality and processing problems. To avoid these repercussions, some companies default to operating “Oral Solid Dose” manufacturing suites at 30% to 40% rh and even as low as 15% to 20% rh.

Where processes are closed or product/process restrictions are beyond the ambient temperature range, controlling the growth of microorganisms may become the primary acceptance criterion, with human comfort (and associated shedding) the secondary requirement. The acceptable range of temperatures and relative humidities varies broadly by region, gowning, and activity (see Chapter 9 in the 2005 ASHRAE Handbook – Fundamentals). Acceptable ranges for pharmaceutical operators are often as broad as 64°F to 78° and 30% to 60% rh. Some have successfully operated with setpoints as high as 70% rh, but operation above 80% rh is not recommended.

Again, the energy savings potential can be great. A facility running at 30% rh or lower likely employs an desiccant dehumidifier, which would not be required if humidity were closer to the 50% range. The savings from relaxing humidity requirements of 30% to 40% rh up to 50% to 60% may reduce energy usage by 10% to 25%.


One of the most significant sustainability developments in pharmaceutical processing in recent years has been the rise of the closed processing in contained microenvironments. Technologies such as sterile barrier and containment isolation, blow-fill-seal, contained process equipment, and “dustless” transfers via split butterfly valves, continuous liners, inflatable seals, and numerous others have redefined pharmaceutical HVAC.

While intended for operator protection, improved sterility assurance, or yield enhancement these technologies have effectively moved the critical environment closer to the process. They have made the occupied environment a secondary zone, reducing the need for contamination control via dilution from HVAC.
As one prominent architect put it when referring to a new sterile processing suite containing a complete barrier isolation line: “We’re just building the garage to park the process team’s Ferrari in …” As these technologies continue to reduce the need for highly controlled room environments, the opportunities for greater energy savings will continue to expand.


As the drive for sustainability and energy efficiency across the world continues, clever engineers will find ways to improve systems and reduce the energy consumption of HVAC for pharmaceutical manufacturing. But engineered systems can’t generate savings as large as can be achieved by collaboration with a cross-functional team to set well-reasoned and scientifically sound goals.ES